Important Things Internists Should Know about Sodium-Glucose Co-Transporter 2 Inhibitors

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Christopher Oleynick
Pouya Motazedian
Graeme Prosperi-Porta


Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are a relatively new class of medications available in Canada used in the treatment of type 2 diabetes mellitus (T2DM). There is an abundance of emerging literature that these drugs are not only effective in the treatment of T2DM but also offer robust clinical benefits for renal disease, cardiovascular disease, and congestive heart failure. Despite the clinical benefits, SGLT-2 inhibitors may be underutilized as some physicians are unfamiliar with the medications or are concerned about their side-effect profile. Given the high prevalence of T2DM and the above comorbidities frequently encountered within Internal Medicine, it is important for internists to be familiar with SGLT-2 inhibitors. This is a short article encapsulating important aspects about these medications that we believe internists should know.

Les inhibiteurs du cotransporteur sodium-glucose de type 2 (SGLT-2) sont une classe relativement nouvelle de médicaments offerts au Canada et utilisés dans le traitement du diabète de type 2 (DT2). Une profusion de nouvelles études montre que ces médicaments sont non seulement efficaces dans le traitement du DT2, mais qu’ils offrent également de solides avantages cliniques pour les maladies rénales, les maladies cardiovasculaires et l’insuffisance cardiaque congestive. Malgré ces avantages cliniques, les inhibiteurs du SGLT-2 sont peut-être sous-utilisés, car certains médecins ne connaissent pas ces médicaments ou s’inquiètent de leur profil d’effets secondaires. Étant donné la forte prévalence du DT2 et les affections comorbides susmentionnées fréquemment rencontrées en médecine interne, il est important que les internistes connaissent bien les inhibiteurs du SGLT-2. Voici un court article qui résume les aspects importants de ces médicaments que les internistes devraient connaître.

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